Recrutement progressif de tissu musculaire/nerveux excitable par utilisation de parametres de stimulation electrique haut debit

Gradual recruitment of muscle/neural excitable tissue using high-rate electrical stimulation parameters

Abstract

La présente invention concerne un système neurostimulateur (170) qui stimule un tissu musculaire ou nerveux excitable par l'intermédiaire de multiples électrodes (E1, E2, ... En) assez rapidement pour induire une décharge neurale stochastique, ce qui permet de restaurer une activité neurale « spontanée ». Le type de stimulation produite par le neurostimulateur implique l'utilisation d'un signal de stimulation pulsatile haut débit, par exemple supérieur à environ 2000 Hz, produit par un générateur d'impulsions haut débit (172). Le flux d'impulsions produit par ce générateur d'impulsions haut débit est modulé en amplitude dans un circuit pilote de sortie (176) à l'aide d'informations de commande fournies par un élément de commande de modulation (178). Une telle modulation pulsatile modulée en amplitude exploite les subtiles différences électrophysiologiques entre des cellules comprenant du tissu excitable, afin de désynchroniser des potentiels d'action au sein de la population de tissu excitable. Une telle désynchronisation induit une distribution plus large des seuils de population et une plus grande plage dynamique électrique, ce qui permet de mieux imiter des caractéristiques de recrutement biologique.
A neurostimulator system (170) stimulates excitable muscle or neural tissue through multiple electrodes (E1, E2, ... En) fast enough to induce stochastic neural firing, thereby acting to restore 'spontaneous' neural activity. The type of stimulation provided by the neurostimulator involves the use of a high rate, e.g., greater than about 2000 Hz, pulsitile stimulation signal generated by a high rate pulse generator (172). The stream of pulses generated by the high rate pulse generator is amplitude modulated in an output driver circuit (176) with control information, provided by a modulation control element (178). Such amplitude-modulated pulsitile stimulation exploits the subtle electro physiological differences between cells comprising excitable tissue in order to desynchronize action potentials within the population of excitable tissue. Such desynchronization induces a wider distribution of population thresholds, as well as a wider electrical dynamic range, thereby better mimicking biological recruitment characteristics.

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NO-Patent Citations (1)

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    See also references of EP 1417001A2

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