Sulfatases et leurs methodes d'utilisation

Sulfatases and methods of use thereof

Abstract

L'invention porte sur de nouvelles sulfatases et leurs polypeptides associés et sur des compositions d'acides nucléiques utilisables dans différentes applications dont des diagnostics et le criblage d'agents thérapeutiques. L'invention porte également sur des méthodes d'inhibition des angiogenèses d'origine tumorale, et sur des méthodes de traitement de maladies associées, en particulier par administration d'un inhibiteur desdites sulfatases.
Novel sulfatases and polypeptides related thereto, as well as nucleic acid compositions encoding the same, are provided. The subject polypeptides and nucleic acid compositions find use in a variety of applications, including various diagnostic and therapeutic agent screening applications. Also provided are methods of inhibiting tumor-induced angiogenesis and methods of treating disease conditions associated therewith, particularly by administering an inhibitor of a subject sulfatase.

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Patent Citations (2)

    Publication numberPublication dateAssigneeTitle
    WO-0155411-A2August 02, 2001Millennium Pharmaceuticals, Inc.Human sulfatases
    WO-02059327-A2August 01, 2002The Regents Of The University Of CaliforniaSulfatases and methods of use thereof

NO-Patent Citations (1)

    Title
    MARIMOTO-TOMITA M. ET AL: 'Cloning and characterization of two extra cellular heparin-degrading andosulfates in mice and humans.' JOURNAL OF BIOLOGICAL CHEMISTRY. vol. 277, no. 51, 20 December 2002, pages 49175 - 49185, XP002989135

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